Cell Xtreme

Super-Resolution Imaging Super-Resolution Imaging

Cell Xtreme is an advanced super-resolution platform combining fluorescence-based MI-SIM with label-free Optical Diffraction Tomography technology. This correlative approach combines the molecular specificity of fluorescence imaging with the complete spatial context provided by label-free imaging.

ODT reconstructs three-dimensional refractive index maps of living samples without fluorescent labels or damaging high-intensity illumination. Together with MI-SIM and AI-supported image segmentation, Cell Xtreme provides detailed information about cellular architecture, molecular targets and dynamic biological processes while maintaining cell viability.

Features

Integrated MI-SIM and label-free ODT imaging
Fluorescence super-resolution down to 60 nm
Label-free tomographic resolution down to 130 nm
Volumetric ODT imaging in less than one second
No Z-stacking required for ODT volume acquisition
Minimal phototoxicity for continuous long-term imaging
AI segmentation of cellular structures
Identification of nuclei, chromatin, nucleoli, lipid droplets and cell boundaries
Multiplex imaging with fewer fluorescent labels
Digital registration of SIM and ODT images
Multi-site imaging and sample overview tools
Intelligent event triggering and feedback microscopy
Hybrid tracking using frequent ODT imaging and targeted SIM acquisition

Technology

Super-Resolution Imaging

Super-resolution imaging includes advanced microscopy techniques that overcome the diffraction limit of conventional light microscopy. While standard optical microscopes typically cannot distinguish structures closer than approximately 200 nm, super-resolut...
Read More